Cox C E
J Int Med Res. 1979;7(5):370-4. doi: 10.1177/030006057900700506.
A clinical trial involving forty hospitalized patients with urinary tract infections was conducted to compare the effectiveness and tolerance of four dosage regimens of netilmicin: 1, 2, 3, and 4 mg/kg administered twice daily for 7 or 8 days. Each of the dosages was effective and the first three were equally well tolerated. At 4 mg/kg there was one case of renal dysfunction possibly related to netilmicin therapy. Serum concentrations of the drug measured 1 hour after injection were dose-related, as were those measured 1 hour before administration; no appreciable accumulation occurred with any of the regimens.
一项针对40名住院尿路感染患者的临床试验开展，以比较奈替米星四种给药方案的有效性和耐受性：每日两次，每次1、2、3和4mg/kg，持续7或8天。每种剂量均有效，前三种的耐受性相当。4mg/kg时有1例肾功能障碍可能与奈替米星治疗有关。注射后1小时测得的药物血清浓度与剂量相关，给药前1小时测得的浓度也如此；任何一种方案均未出现明显蓄积。
