Konstantinov D, Stanoeva L, Yawalkar S J
J Int Med Res. 1979;7(5):443-8. doi: 10.1177/030006057900700519.
Fifty hospitalized infants and small children in the age-group of 3 months to 2 years admitted with scabies were treated with 5 applications of either 10% crotamiton cream or lotion on consecutive days. In this trial, the second to be performed exclusively in infants and young children, an improvement in itching was observed in all patients within 3 days of starting the treatment and the examination on Day 7 showed absence of skin lesions in all patients. Crotamiton cream as well as lotion rendered a 100% cure rate. All patients, including those having secondary pyoderma and/or eczematization tolerated the treatment with crotamiton cream and lotion well and no adverse reactions, either due to the topical application or to the transcutaneous systemic absorption of crotamiton, were reported. Post-treatment laboratory investigations did not reveal any unwanted effect due to transcutaneous systemic absorption of crotamiton on the blood, kidneys or liver. Crotamiton is the only scabicide available today which displays not only antiprurtic but also marked antibacterial properties. It is especially indicated in the treatment of scabies in children as they are very prone to secondary bacterial infection following scratching. In view of its good efficacy and excellent tolerability the 5-application treatment schedule, with crotamiton cream applied to the whole body from the chin downward, can therefore be recommended as an optimum form of treatment for scabies in infants and young children.
五十名年龄在3个月至2岁之间因疥疮入院的住院婴幼儿，连续5天每天使用10%克罗米通乳膏或洗剂涂抹。在本次专门针对婴幼儿进行的试验中，所有患者在开始治疗后3天内瘙痒症状均有所改善，第7天检查时所有患者均无皮肤损伤。克罗米通乳膏和洗剂的治愈率均为100%。所有患者，包括患有继发性脓疱病和/或湿疹的患者，对克罗米通乳膏和洗剂的治疗耐受性良好，未报告因局部应用或克罗米通经皮全身吸收引起的任何不良反应。治疗后的实验室检查未发现克罗米通经皮全身吸收对血液、肾脏或肝脏有任何不良影响。克罗米通是目前唯一一种不仅具有止痒作用，还具有显著抗菌特性的杀疥虫剂。它特别适用于治疗儿童疥疮，因为儿童在搔抓后极易继发细菌感染。鉴于其良好的疗效和极佳的耐受性，因此推荐采用5次涂抹的治疗方案，即从下巴向下将克罗米通乳膏涂抹于全身，作为婴幼儿疥疮的最佳治疗方式。
