Tomasi T B, Katz L
Clin Exp Immunol. 1971 Jul;9(1):3-10.
Analysis of the sera of seventeen patients with a selective deficiency of IgA revealed that 24% gave a precipitin reaction on gel diffusion with normal bovine serum and milk. None of 100 normal adults and only one of approximately 500 patients with various diseases without an IgA deficiency had precipitins when studied by this same technique. Analysis of the nature of this reaction revealed that an IgG type antibody present in the human sera was reacting with the Fc fragment of the IgM present in bovine milk and serum. An immunologically identical reaction occurred with goat and sheep, and reactions of partial identity with horse and pig sera. No reactions were found with sera from other species including man. In two of the IgA deficient sera additional but much weaker precipitin lines were noted with cow milk. These data are consistent with the hypothesis that oral immunization with the highly antigenic macroglobulin present in cow milk was facilitated by the mucosal antibody defect accompanying the IgA deficiency.
对17例选择性IgA缺乏患者的血清分析显示，24%的患者在与正常牛血清和牛奶进行凝胶扩散时出现沉淀反应。采用相同技术研究时，100名正常成年人中无人出现沉淀素，约500例无IgA缺乏的各种疾病患者中只有1人出现沉淀素。对该反应性质的分析表明，人血清中存在的IgG型抗体与牛奶和血清中存在的IgM的Fc片段发生反应。与山羊和绵羊血清发生免疫相同反应，与马和猪血清发生部分相同反应。未发现与包括人在内的其他物种血清发生反应。在两份IgA缺乏血清中，用牛奶检测到额外但较弱的沉淀线。这些数据与以下假设一致，即伴随IgA缺乏的黏膜抗体缺陷促进了牛奶中高抗原性巨球蛋白的口服免疫。
