Ramphal R, Cogliano R C, Shands J W, Small P A
Infect Immun. 1979 Sep;25(3):992-7. doi: 10.1128/iai.25.3.992-997.1979.
This paper reports studies showing the effects of serum antibody upon influenza infection at two different sites: the trachea and lung. Tracheal desquamation, pulmonary consolidation, death, and virus shedding were examined after infection of mice with a lethal A/Port Chalmers/1/73 (H3N2) influenza virus. Immune serum administered intraperitoneally before infection prevented death and pulmonary consolidation and also significantly lowered lung virus shedding as compared with controls receiving normal serum. However, this protection did not extend to the ciliated epithelium of the trachea because serum antibody did not prevent desquamation of the trachea or significantly decrease viral yield from the trachea. These results indicate that serum antibody is protective against severe pulmonary parenchymal disease but not for disease of the ciliated epithelium.
本文报道了一些研究，这些研究展示了血清抗体在两个不同部位（气管和肺部）对流感感染的影响。在用致死性的A/克赖斯特彻奇港/1/73（H3N2）流感病毒感染小鼠后，检测了气管脱屑、肺部实变、死亡和病毒排出情况。与接受正常血清的对照组相比，在感染前经腹腔注射免疫血清可预防死亡和肺部实变，并且还能显著降低肺部的病毒排出量。然而，这种保护作用并未扩展到气管的纤毛上皮，因为血清抗体并不能防止气管脱屑，也不能显著降低气管中的病毒产量。这些结果表明，血清抗体可预防严重的肺实质疾病，但对纤毛上皮疾病无效。
