Breitschwerdt E B, Root C R
J Am Vet Med Assoc. 1979 Jul 15;175(2):181-6.
Hyponatremia with simultaneous renal sodium loss was associated with the inappropriate secretion of antidiuretic hormone in a dog with heartworm disease. Antidiuresis caused expansion of extracellular fluid volume, which induced renal salt wasting and a negative sodium balance. The combination of water retention, salt wasting, and inactivation of intracellular solute contributes to the decrease in serum sodium concentration. Water intoxication due to hypotonicity of body gluids induced anorexia, depression, weakness, and incoordination.
患有心丝虫病的犬出现低钠血症并伴有肾钠丢失，这与抗利尿激素分泌不当有关。抗利尿导致细胞外液量增加，进而引起肾性盐耗竭和负钠平衡。水潴留、盐耗竭和细胞内溶质失活共同导致血清钠浓度降低。由于体液低渗引起的水中毒导致厌食、抑郁、虚弱和共济失调。
