Bull World Health Organ. 1971;45(1):125-42.
Increased understanding of the nature and variety of immunodeficiency states in man is rapidly accumulating both from studies of human patients and from experimental work on the immune response in animals. Progress is evident in the development of diagnostic tests for deficiencies in both humoral and cellular mechanisms of immunity, and in the introduction of new forms of therapy-for example, the grafting of lymphoid cells. Studies of immunodeficiency provide the most direct evidence concerning the nature of the immune response in man, and hence are of wide general interest. In this paper, current knowledge and concepts are summarized, a logical classification is presented, and recommendations are made for the investigation and treatment of these disorders.
无论是对人类患者的研究,还是对动物免疫反应的实验工作,都在迅速积累对人类免疫缺陷状态的性质和多样性的更多认识。在体液免疫和细胞免疫机制缺陷的诊断测试开发方面,以及在引入新的治疗形式(例如淋巴样细胞移植)方面,进展明显。免疫缺陷研究提供了关于人类免疫反应性质的最直接证据,因此具有广泛的普遍意义。本文总结了当前的知识和概念,提出了合理的分类,并对这些疾病的调查和治疗提出了建议。