Berger H, Hühner S
Arch Dermatol Forsch. 1975;252(2):119-30.
From 275 specimens of all sorts of basal cell epitheliomas the new formation of elastic fibers was histologically investigated by means of selective elastic tissue stains such as orcein and resorcinfuchsin. In nearly one third of the basal cell epitheliomas newly formed elastic fibers could be observed in the stroma. In places where a new formation of elastic fibers was demonstrated fibroblasts and mast cells (toluidine blue stain) were unusually numerous. Apparently the influence of the growing tumor masses of basal cell epitheliomas leads to a dermo-epidermal interaction in the form of 1. increase of mast cells 2. stimulation of fibroblasts 3. new formation of elastic fibers. The observation suggest that there exists a relationship between the above noted findings. Due to the dermo-epithelial interaction (even in senile skin) in the stroma of basal cell epithelioma fibroblasts can be stimulated to such a degree that they regain the ability to produce elastic fibers-a function which usually is greatly diminished with increasing age. The findings seem to be important from the view point of rejuvenation of aging human skin.
从275份各类基底细胞上皮瘤标本中，借助诸如地衣红和间苯二酚品红等选择性弹性组织染色法，对弹性纤维的新生成进行了组织学研究。在近三分之一的基底细胞上皮瘤中，可在基质中观察到新生成的弹性纤维。在证实有弹性纤维新生成的部位，成纤维细胞和肥大细胞（甲苯胺蓝染色）异常增多。显然，基底细胞上皮瘤不断生长的肿瘤团块的影响导致了一种真皮 - 表皮相互作用，表现为：1. 肥大细胞增多；2. 成纤维细胞受到刺激；3. 弹性纤维新生成。这些观察结果表明上述发现之间存在关联。由于在基底细胞上皮瘤的基质中存在真皮 - 上皮相互作用（即使在老年皮肤中），成纤维细胞可被刺激到一定程度，以至于它们重新获得产生弹性纤维的能力——而这种功能通常会随着年龄增长而大幅减弱。从人类衰老皮肤年轻化的角度来看，这些发现似乎很重要。
