Kalliomäki P L, Sutinen S, Kelhä V, Lakomaa E, Sortti V, Sutinen S
Br J Ind Med. 1979 Aug;36(3):224-30. doi: 10.1136/oem.36.3.224.
This study describes various post-mortem examinations of the lungs of a shipyard arc welder. These investigations comprised morphological methods, including gross pathology and radiography, histological and ultrastructural examinations, chemical analysis of lung tissue, and sensitive magnetic measurements, which can now be used to detect magnetic contaminants, such as welding fume, in human tissue. Such methods can also show the distribution of contaminants. The amount of welding-fume contaminants was low, only 110 mg. The contaminant iron seemed to represent only 10% of the total iron chemically analysed in lung tissue. The concentration of the total iron was 4-10 times higher than that in control tissue. Contaminants tended to collect in the central areas of the lungs. Two concentration centres could be observed in each lung, one anterior and one posterior. There was slight fibrosis around pigmented areas. Histological findings were similar to those of previous studies. Transmission electron micrographs showed that enlarged lysosomes of macrophages contained electron-dense granules, 450 nm to less than 5 nm in diameter, which formed aggregates and short chains, and resembled welding-fume particles in the breathing zone. Our results show the value of studying the same material by a number of inter-related methods.
本研究描述了对一名造船厂电弧焊工肺部进行的各种尸检情况。这些调查包括形态学方法，如大体病理学和放射学检查、组织学和超微结构检查、肺组织化学分析以及灵敏的磁性测量，现在可利用这些测量来检测人体组织中的磁性污染物，如焊接烟尘。这些方法还能显示污染物的分布情况。焊接烟尘污染物的量很低，仅110毫克。污染物铁似乎仅占肺组织化学分析总铁量的10%。总铁浓度比对照组织高4至10倍。污染物倾向于在肺的中央区域聚集。每个肺中可观察到两个浓度中心，一个在前，一个在后。色素沉着区域周围有轻微纤维化。组织学结果与先前研究相似。透射电子显微镜照片显示，巨噬细胞肿大的溶酶体含有电子致密颗粒，直径为450纳米至小于5纳米，这些颗粒形成聚集体和短链，类似于呼吸带中的焊接烟尘颗粒。我们的结果表明了通过多种相互关联的方法研究同一材料的价值。
