Mintz B, Domon M, Hungerford D A, Morrow J
Science. 1972 Feb 11;175(4022):657-9. doi: 10.1126/science.175.4022.657.
The relation of cellular sex genotype to phenotype was examined in seminal vesicles of adult allophenic mice with cellular sex chromosome mosaicism. Each animal originated from conjoined blastomeres of an embryo of female (XX) and one of male (XY) constitution, from different inbred strains. Cells of both sexes were detected in bone marrow and certain other somatic tissues; cellular sex of seminal vesicles was deduced from strain-associated electrophoretic variants of proteins coded for at autosomal loci. Seminal vesicles composed partly or entirely of female cells were found in male and pseudohermaphrodite individuals. In a pseudohermaphrodite, both allelic variants of the tissue-specific normal male seminal vesicle protein (Svp-locus) were present, signifying that female as well as male cells were synthesizing the protein. Male-determining factors on the Y chromosome are thus not required in cells that differentiate into functional seminal vesicles.
在具有细胞性染色体嵌合体的成年异基因型小鼠的精囊中，研究了细胞性基因型与表型的关系。每只动物都起源于来自不同近交系的雌性（XX）胚胎和雄性（XY）胚胎的联体卵裂球。在骨髓和某些其他体细胞组织中检测到了两性的细胞；精囊的细胞性别是根据常染色体位点编码的蛋白质的品系相关电泳变体推断出来的。在雄性和假两性畸形个体中发现了部分或完全由雌性细胞组成的精囊。在一个假两性畸形个体中，组织特异性正常雄性精囊蛋白（Svp位点）的两个等位基因变体都存在，这表明雌性和雄性细胞都在合成这种蛋白质。因此，分化为功能性精囊的细胞不需要Y染色体上的雄性决定因子。
