植入阿久津全人工心脏后绵羊的形态学改变。

Henson E C, Weaver D Q, Lockard V G, Takano H, Takagi H, Akutsu T, Arhelger R B, Brunson J G

Am J Pathol. 1972 Feb;66(2):331-42.

The present report describes morphologic alterations produced in sheep after implantation of a four-chambered total artificial heart. Two groups of sheep were studied. The first group was given no special antishock therapy and had an average survival time of 25.8 hours. Major morphologic changes produced in the first group were focal infarction and massive hemorrhage of the large and small bowel, ascites, severely altered lungs and multiple infarcts in the kidneys. The second group of sheep was given antishock therapy and showed an average survival time of 35.4 hours. Severe morphologic alterations in this group were generally absent in all organs except the lungs, which showed varying degrees of congestion, hemorrhage, edema, pneumonitis and atelectasis. Death in both of the above groups was due to development of irreversible hypotension and respiratory failure.

本报告描述了植入四腔全人工心脏后绵羊所产生的形态学改变。研究了两组绵羊。第一组未接受特殊抗休克治疗，平均存活时间为25.8小时。第一组产生的主要形态学变化为大小肠局灶性梗死和大量出血、腹水、肺部严重改变以及肾脏多发性梗死。第二组绵羊接受了抗休克治疗，平均存活时间为35.4小时。除肺部外，该组所有器官一般均未出现严重形态学改变，肺部表现出不同程度的充血、出血、水肿、肺炎和肺不张。上述两组的死亡均归因于不可逆性低血压和呼吸衰竭的发生。