Kozaki T
Nihon Seikeigeka Gakkai Zasshi. 1979 Jul;53(7):741-59.
Total knee prostheses for a dog were developed and were inserted into knee joints of seven adult dogs to study the mobility of the artificial joint, the degree of fixation to bone and the durability of the prosthesis, to examine the reactions in the surrounding tissues and the internal organs in the JIKEI total knee prosthesis in clinical use. As a result of surgery, it was proved that the length in the hinged part of the prosthesis needed to be seventy percent of the length of the excised area of the joint to gain good mobility and supportability of the knee joint after surgery. As a result of findings based on necropsy, wear at the hinged part of the prosthesis was mild and debris caused in wear was not harmful for the living body if breakage does not occur there. Histopathological findings revealed that collagenous fibrous tissue with new bone formation was observed on the inner wall of the bone around the stem of the prosthesis four months after surgery. Then it was proved that the fixation of the prosthesis to the bone was sufficient. Therefore the author would like to mention that bone cement is not necessary for the fixation between bone and prostheses. The JIKEI total knee prosthesis (universal type) based on the results of these experimental studies has been developed and was used to the clinical cases. The clinical results until four years after surgery have been most satisfactory with loss of pain, good supportability and movement of joints in almost all of the cases.
研发了犬用全膝关节假体，并将其植入7只成年犬的膝关节，以研究人工关节的活动度、与骨的固定程度及假体的耐用性，同时检查临床使用的JIKEI全膝关节假体周围组织和内部器官的反应。手术结果表明，假体铰链部分的长度需为关节切除区域长度的70%，才能在术后获得良好的膝关节活动度和支撑性。尸检结果显示，假体铰链部分的磨损轻微，若未发生破损，磨损产生的碎屑对活体无害。组织病理学检查结果显示，术后4个月，在假体柄周围骨的内壁观察到有新骨形成的胶原纤维组织。由此证明假体与骨的固定充分。因此，作者认为骨与假体之间的固定无需使用骨水泥。基于这些实验研究结果，已研发出JIKEI全膝关节假体（通用型）并应用于临床病例。术后4年的临床结果非常令人满意，几乎所有病例都实现了疼痛消失、关节支撑性良好且活动自如。
