人类红细胞乙酰胆碱酯酶的基因变异
Genetic variation in human erythrocyte acetylcholinesterase.
作者信息
Coates P M, Simpson N E
出版信息
Science. 1972 Mar 31;175(4029):1466-7. doi: 10.1126/science.175.4029.1466.
PMID:5013676
Abstract
A method for solubilization of human erythrocyte membranes was developed and used to survey 70 unselected human blood samples for isozymic variation of stromal acetylcholinesterase. Three variants were observed. Pedigrees of families studied by this method indicated that this variation represented the phenotypic expression of two codominant alleles at a single locus.
摘要
已开发出一种溶解人红细胞膜的方法，并用于检测70份未经挑选的人血样本中基质乙酰胆碱酯酶的同工酶变异情况。观察到三种变异体。用该方法研究的家族谱系表明，这种变异代表了单个基因座上两个共显性等位基因的表型表达。
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