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一名黑人女孩患僵人综合征。

Stiff man syndrome in a black girl.

作者信息

Isaacs H

出版信息

J Neurol Neurosurg Psychiatry. 1979 Nov;42(11):988-94. doi: 10.1136/jnnp.42.11.988.

DOI:10.1136/jnnp.42.11.988
PMID:501375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC490391/
Abstract

A patient suffering from severe and continuous muscular spasms is presented. The condition has been classified as the stiff man syndrome and is the first case recorded of the condition in a young African girl. The electrophysiological, biochemical, histochemical, and ultramicroscopic aspects of this disorder have been studied. The spasm appears to be related to overproduction of brain noradrenaline.

摘要

现报告一名患有严重持续性肌肉痉挛的患者。该病症已被归类为僵人综合征，是在一名年轻非洲女孩中记录到的首例该病症病例。已对该疾病的电生理、生化、组织化学和超微结构方面进行了研究。痉挛似乎与脑去甲肾上腺素分泌过多有关。

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1
Stiff man syndrome in a black girl.一名黑人女孩患僵人综合征。
J Neurol Neurosurg Psychiatry. 1979 Nov;42(11):988-94. doi: 10.1136/jnnp.42.11.988.
2
Stiff-man syndrome updated.僵人综合征最新进展。
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Electrophysiological studies on the "stiff-man" syndrome.“僵人”综合征的电生理研究
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引用本文的文献

1
Pediatric stiff-person syndrome and related disorders: A systematic review.小儿僵人综合征及相关疾病：一项系统综述。
Neurol Sci. 2025 Aug 19. doi: 10.1007/s10072-025-08397-z.
2
Childhood onset of stiff-man syndrome.儿童期发作的僵人综合征。
JAMA Neurol. 2013 Dec;70(12):1531-6. doi: 10.1001/jamaneurol.2013.4442.
3
[Primary neurogenic and myogenic disorders of posture].[姿势的原发性神经源性和肌源性疾病]

本文引用的文献

1
A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study.一例非甲状腺源性严重高代谢伴线粒体呼吸控制维持缺陷：一项临床、生化及形态学相关性研究。
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2
QUANTITATIVE DETERMINATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE.尿中变肾上腺素和去甲变肾上腺素的定量测定
J Lab Clin Med. 1964 Sep;64:469-84.
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"STIFF-MAN" SYNDROME: A REVIEW OF THE LITERATURE, REPORT OF THREE ADDITIONAL CASES AND DISCUSSION OF PATHOPHYSIOLOGY AND THERAPY.
Orthopade. 2004 May;33(5):583-90. doi: 10.1007/s00132-003-0621-0.
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Electrophysiological evaluation of the stiff-man syndrome: further data.僵人综合征的电生理评估：更多数据
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Stiff man syndrome: clinical and laboratory findings in eight patients.僵人综合征：8例患者的临床及实验室检查结果
J Neurol. 1994 Jan;241(3):157-66. doi: 10.1007/BF00868343.
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Stiff man syndrome: neurophysiological findings in eight patients.
J Neurol. 1995 Feb;242(3):134-42. doi: 10.1007/BF00936885.
7
Syndromes of abnormal muscular activity: overlap between continuous muscle fibre activity and the stiff man syndrome.异常肌肉活动综合征：持续性肌纤维活动与僵人综合征之间的重叠
J Neurol Neurosurg Psychiatry. 1983 Mar;46(3):241-7. doi: 10.1136/jnnp.46.3.241.
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Neurological and pharmacological evaluation of a case of stiff-man syndrome.僵人综合征一例的神经学与药理学评估
J Neurol. 1980;223(2):127-33. doi: 10.1007/BF00313175.
“僵人”综合征：文献综述、三例补充病例报告及病理生理学与治疗探讨
Mayo Clin Proc. 1964 Feb;39:131-44.
4
ALTERED NEURON POPULATION IN L7 SEGMENT OF DOGS WITH EXPERIMENTAL HIND-LIMB RIGIDITY.实验性后肢僵硬犬L7节段神经元群的改变
Am J Physiol. 1963 Sep;205:606-16. doi: 10.1152/ajplegacy.1963.205.3.606.
5
A new and effective drug in the treatment of the stiff-man syndrome: preliminary report.一种治疗僵人综合征的新型有效药物：初步报告。
Proc Staff Meet Mayo Clin. 1963 May 22;38:203-12.
6
The "stiff-man" syndrome. A report of two further cases.“僵人”综合征。又两例报告。
Arch Neurol. 1960 Oct;3:448-56. doi: 10.1001/archneur.1960.00450040098012.
7
Interneurones and rigidity of spinal origin.中间神经元与脊髓源性强直
J Physiol. 1959 Jun 11;146(3):594-617. doi: 10.1113/jphysiol.1959.sp006214.
8
A woman with the stiff-man syndrome.一名患有僵人综合征的女性。
Br Med J. 1958 Feb 1;1(5065):265-6. doi: 10.1136/bmj.1.5065.265.
9
Progressive fluctuating muscular rigidity and spasm ("stiff-man" syndrome); report of a case and some observations in 13 other cases.进行性波动性肌肉僵硬和痉挛（“僵人”综合征）；1例报告及对其他13例的一些观察
Proc Staff Meet Mayo Clin. 1956 Jul 25;31(15):421-7.
10
Stiff-man syndrome. Two patients treated with diazepam.
JAMA. 1966 Jan 17;195(3):222-4. doi: 10.1001/jama.195.3.222.