过敏性休克中的循环内皮细胞与动脉内皮有丝分裂

Circulating endothelial cells and arterial endothelial mitosis in anaphylactic shock.

作者信息

Wright H P, Glacometti N J

出版信息

Br J Exp Pathol. 1972 Feb;53(1):1-4.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072382/

Abstract

Sensitized guinea-pigs received a shocking dose of ovalbumin. Within 8 min endothelial cells ranging in numbers between 24·0 and 13·88/1000 leukocytes were recovered from the peripheral blood. Control animals had counts between 0·00 and 4·40. Subsequent injection of T-H and autoradiographic study of Hautchen preparations of aortic endothelium showed a 3-fold increase in mitosis in the shocked animals when compared with controls. The increase in mitosis represents the repair process following endothelial distruction caused by anaphylactic shock.

摘要

致敏豚鼠接受了一剂引起休克剂量的卵清蛋白。8分钟内，从外周血中回收的内皮细胞数量在每1000个白细胞中有24.0至13.88个。对照动物的计数在0.00至4.40之间。随后对主动脉内皮的表皮制剂进行T-H注射和放射自显影研究表明，与对照相比，休克动物的有丝分裂增加了3倍。有丝分裂的增加代表了过敏性休克引起的内皮破坏后的修复过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e60/2072382/cd11856ed59c/brjexppathol00415-0013-a.jpg

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本文引用的文献

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Experimental induction of athero-arteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. I. Effect of repeated injections of horse serum in rabbits fed a dietary cholesterol supplement.通过动脉过敏性损伤与富含脂质饮食的协同作用实验诱导动脉粥样硬化。I. 在喂食胆固醇补充剂的兔子中重复注射马血清的效果。

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A modified technique for producing "en face" (Häutchen) preparations of endothelium for autoradiography.一种用于制作内皮“表面”（薄层）标本以进行放射自显影的改良技术。

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Effect of removal of cholesterol diet upon serum sickness-cholesterol-induced atherosclerosis.去除胆固醇饮食对血清病-胆固醇诱导的动脉粥样硬化的影响。

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Hypothesis. An immunological view of atherogenesis.假说：动脉粥样硬化形成的免疫学观点。

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Increased mitotic activity in rabbit endothelium after endotoxin. An autoradiographic study.内毒素作用后兔内皮细胞有丝分裂活性增加。一项放射自显影研究。

Lab Invest. 1971 Apr;24(4):318-20.

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