去甲肾上腺素和多巴胺：皮摩尔范围内的质量碎片分析法测定
Norepinephrine and dopamine: assay by mass fragmentography in the picomole range.
作者信息
Koslow S H, Cattabeni F, Costa E
出版信息
Science. 1972 Apr 14;176(4031):177-80. doi: 10.1126/science.176.4031.177.
PMID:5014439
Abstract
Gas chromatography-mass spectrometry makes possible the simultaneous measurement of norepinephrine and dopamine in concentrations of 0.1-milligram tissue samples. Specificity of the assay is confirmed both by the retention time of the compound and by the mass to charge ratio of the fragments recorded. The sensitivity is of the order of 0.5 picomole, and linearity of the response is maintained up to at least 200 picomoles.
摘要
气相色谱 - 质谱联用技术能够同时测定0.1毫克组织样本中去甲肾上腺素和多巴胺的浓度。该检测方法的特异性通过化合物的保留时间以及所记录碎片的质荷比得以确认。灵敏度约为0.5皮摩尔，并且响应的线性至少可维持至200皮摩尔。
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