Whitfield C R, Chan W H, Sproule W B, Stewart A D
Br Med J. 1972 Apr 8;2(5805):85-6. doi: 10.1136/bmj.2.5805.85.
The normal range and trends of the ratio between lecithin and sphingomyelin in the amniotic fluid, estimated on thin-layer chromatograms, have been established for the last trimester. The accuracy of the ratio as an index of fetal lung development and of the risk of neonatal respiratory distress has been confirmed. The usual increase in the ratio towards term was not found in some pregnancies complicated by diabetes or severe rhesus incompatibility. Determination of the ratio may prove a valuable guide in the management of pregnancies with these complications.
通过薄层色谱法估算的羊水卵磷脂与鞘磷脂比值在妊娠晚期的正常范围及变化趋势已经确定。该比值作为胎儿肺发育指标及新生儿呼吸窘迫风险指标的准确性已得到证实。在一些并发糖尿病或严重恒河猴血型不相容的妊娠中，未发现该比值随孕周增加的常见变化。对于患有这些并发症的妊娠管理而言，该比值的测定可能是一项有价值的指导。
