Sive J, Green R, Metz J
J Clin Pathol. 1972 Mar;25(3):194-7. doi: 10.1136/jcp.25.3.194.
The effect of trimethoprim in various concentrations was tested on the folate-dependent deoxyuridylate methylation reaction in human bone marrow cultures. A slight effect was demonstrated at a concentration similar to that achieved in the plasma in patients taking the conventional therapeutic dose of trimethoprim. When a tenfold greater concentration was used, the effect became more pronounced. These findings are in agreement with reports of some mild haematological changes associated with the use of trimethoprim and offer an explanation for such changes.
测试了不同浓度甲氧苄啶对人骨髓培养物中叶酸依赖性脱氧尿苷酸甲基化反应的影响。在与服用传统治疗剂量甲氧苄啶的患者血浆中所达到的浓度相似的情况下，显示出轻微影响。当使用高十倍的浓度时，这种影响变得更加明显。这些发现与一些关于使用甲氧苄啶相关的轻度血液学变化的报道一致，并为这些变化提供了解释。
