Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis and biological activity of homocysteine derivatives bridged to adenine. - Suppr | 超能文献

Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis and biological activity of homocysteine derivatives bridged to adenine.

作者信息

Coward J K, Sweet W D

出版信息

J Med Chem. 1972 Apr;15(4):381-4. doi: 10.1021/jm00274a013.

DOI:10.1021/jm00274a013

Abstract

摘要

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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 1. Modification of the amino acid portion of S-adenosylhomocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。1. S-腺苷高半胱氨酸氨基酸部分的修饰。

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Potential inhibitor of S-adenosylmethionine-dependent methyltransferases. 2. Modification of the base portion of S-adenosylhomocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。2. S-腺苷同型半胱氨酸碱基部分的修饰。

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Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog.S-腺苷同型半胱氨酸和S-腺苷同型半胱氨酸亚砜对儿茶酚-O-甲基转移酶的抑制作用，一种潜在的过渡态类似物。

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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。3. S-腺苷同型半胱氨酸糖部分的修饰。

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