Calman K C
Gut. 1975 Jun;16(6):490-9. doi: 10.1136/gut.16.6.490.
This review set out to answer several questions related to tumour immunology and the gut. It is evident that in patients with gastrointestinal cancer there is a general depression of the immune response and this seems to be correlated with the stage of the disease. Paradoxically a specific immune response against definable tumour antigens can be demonstrated, both cellular and humoral mechanisms being involved although the complexities of this paradox require further analysis. Immunotherapy has been employed in gastrointestinal tumours in a sporadic way. The results suggest that gastrointestinal neoplasms may respond at least as well as other tumours. A firm conclusion awaits the results of controlled trials in which the bulk of the tumour has been effectively dealt with by other means or where combined immunochemotherapy is being used.
本综述旨在回答几个与肿瘤免疫学和肠道相关的问题。显然，在胃肠道癌患者中，免疫反应普遍受到抑制，这似乎与疾病阶段相关。矛盾的是，针对可明确的肿瘤抗原的特异性免疫反应是可以被证实的，细胞和体液机制均参与其中，尽管这一矛盾的复杂性需要进一步分析。免疫疗法已被零星地应用于胃肠道肿瘤。结果表明，胃肠道肿瘤的反应至少与其他肿瘤一样好。要得出确切结论，还需等待对照试验的结果，这些试验中肿瘤的大部分已通过其他方法有效处理，或者正在使用联合免疫化疗。
