大鼠小脑的突触发生：早期甲状腺功能减退和亢进的影响。
Synaptogenesis in the rat cerebellum: effects of early hypo- and hyperthyroidism.
作者信息
Nicholson J L, Altman J
出版信息
Science. 1972 May 5;176(4034):530-2. doi: 10.1126/science.176.4034.530.
PMID:5032356
Abstract
The number of synapses in the molecular layer of the rat cerebellum is reduced by early hypo-and hyperthyroidism within 30 days. Hypothyroidism retards synaptogenesis after 10 days, while hyperthyroidism accelerates synaptogenesis initially, but by 21 days the number of synapses is reduced. The sensitivity of developing synapses to thyroid hormone may permit analysis of the events triggering synaptogenesis.
摘要
大鼠小脑分子层中的突触数量在出生后30天内会因早期甲状腺功能减退和亢进而减少。甲状腺功能减退会在10天后延迟突触形成，而甲状腺功能亢进最初会加速突触形成，但到21天时突触数量会减少。发育中的突触对甲状腺激素的敏感性可能有助于分析触发突触形成的事件。
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