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Synthesis and biologic evaluation of 7-hydroxymethotrexate, 7-methylaminopterin, and 7-methylmethotrexate.

作者信息

Farquhar D, Loo T L

出版信息

J Med Chem. 1972 May;15(5):567-9. doi: 10.1021/jm00275a038.

DOI:10.1021/jm00275a038
PMID:5035289
Abstract
摘要

相似文献

1
Synthesis and biologic evaluation of 7-hydroxymethotrexate, 7-methylaminopterin, and 7-methylmethotrexate.7-羟基甲氨蝶呤、7-甲基氨基蝶呤及7-甲基甲氨蝶呤的合成与生物学评价
J Med Chem. 1972 May;15(5):567-9. doi: 10.1021/jm00275a038.
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Potential folic acid antagonists. 5. Synthesis and biologic evaluation of N 10 -deazapteroic acid and N 10 -deazafolic acid and their 9,10-dehydro derivatives.潜在的叶酸拮抗剂。5. N¹⁰-脱氮蝶酸和N¹⁰-脱氮叶酸及其9,10-脱氢衍生物的合成与生物学评价。
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Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
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Analogues of methotrexate.
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High-dose 7-hydromethotrexate: acute toxicity and lethality in a rat model.
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Renal and hepatic toxicity after high-dose 7-hydroxymethotrexate in the rat.大鼠高剂量7-羟基甲氨蝶呤后的肾和肝毒性
Cancer Chemother Pharmacol. 1994;34(2):119-24. doi: 10.1007/BF00685928.
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Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis.甲氨蝶呤和7-羟基甲氨蝶呤对嘌呤核苷酸生物合成中叶酸依赖性酶的抑制作用差异。
Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):627-9. doi: 10.1042/bj3000627.
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Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.大剂量甲氨蝶呤治疗后7-羟基甲氨蝶呤的动力学
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7-Hydroxy-methotrexate and clinical toxicity following high-dose methotrexate therapy.高剂量甲氨蝶呤治疗后的7-羟基甲氨蝶呤与临床毒性
J Cancer Res Clin Oncol. 1985;109(1):86-8. doi: 10.1007/BF01884261.
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Pharmacokinetics of anticancer drugs in children.儿童抗癌药物的药代动力学
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Clinical pharmacokinetics of drugs used in the treatment of breast cancer.
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