印防己毒素对猫大脑皮层中γ-氨基丁酸的拮抗作用。
Antagonism of GABA by picrotoxin in the feline cerebral cortex.
作者信息
Hill R G, Simmonds M A, Straughan D W
出版信息
Br J Pharmacol. 1972 Apr;44(4):807-9. doi: 10.1111/j.1476-5381.1972.tb07319.x.
Abstract
Picrotoxin and gamma-aminobutyric acid (GABA) were applied by microiontophoresis to an unselected population of neurones in the feline cerebral cortex. Picrotoxin was shown to antagonize the depressant effects of GABA and in addition appeared free of some of the actions of bicuculline which tend to mask GABA antagonism.
摘要
将印防己毒素和γ-氨基丁酸（GABA）通过微离子电泳法施加于猫大脑皮层中未经筛选的神经元群体。结果显示，印防己毒素可拮抗GABA的抑制作用，此外，它似乎没有荷包牡丹碱的某些作用，而荷包牡丹碱的这些作用往往会掩盖GABA的拮抗作用。
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A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish.关于印防己毒素对小龙虾抑制性神经肌肉接头作用的研究。
J Physiol. 1969 Nov;205(2):377-91. doi: 10.1113/jphysiol.1969.sp008972.
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Evidence that bicuculline can both potentiate and antagonize GABA.荷包牡丹碱既能增强γ-氨基丁酸（GABA）的作用，又能拮抗GABA的证据。
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Evaluation of bicuculline as a GABA antagonist.荷包牡丹碱作为γ-氨基丁酸拮抗剂的评估。
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The effect of bicuculline, metrazol, picrotoxin and strychnine on the release of ( 3 H)GABA from rat brain slices.荷包牡丹碱、戊四氮、苦味毒和士的宁对大鼠脑片（³H）γ-氨基丁酸释放的影响。
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Glutamate and gamma-aminobutyric acid in brain.大脑中的谷氨酸和γ-氨基丁酸。
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The effect of bicuculline on the gamma-aminobutyric acid (GABA) receptors of neurons of Periplaneta americana and Helix aspersa.荷包牡丹碱对美洲大蠊和欧洲花园蜗牛神经元γ-氨基丁酸（GABA）受体的作用。
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