油酸、甲苯磺丁脲和羟苯丁酮对华法林与人血清白蛋白结合的影响。

The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin.

作者信息

Wosilait W D, Ryan M P

出版信息

Res Commun Chem Pathol Pharmacol. 1979 Sep;25(3):577-84.

Abstract

Equilibrium dialysis studies showed that, at low levels, stearate, palmitate and oleate enhanced the binding of warfarin by human serum albumin, but at high levels of FFA, warfarin was displaced. Tolbutamide and oxyphenbutazone separately desplaced warfarin, and this dispplacement was reduced by the presence of low concentrations of oleate while at higher concentrations of oleate displacement occurred. Thus, the binding of warfarin was affected in a complex fashion depending upon the drugs present and the concentration of the FFA.

摘要

平衡透析研究表明，在低水平时，硬脂酸、棕榈酸和油酸会增强华法林与人血清白蛋白的结合，但在游离脂肪酸（FFA）水平较高时，华法林会被取代。甲苯磺丁脲和羟基保泰松分别会取代华法林，而低浓度油酸的存在会减少这种取代，而在较高浓度油酸时则会发生取代。因此，华法林的结合受到复杂的影响，这取决于所存在的药物和游离脂肪酸的浓度。