下丘脑外侧损伤后，对甲基对酪氨酸促进恢复的作用。

Facilitation of recovery by -methyl-p-tyrosine after lateral hypothalamic damage.

作者信息

Glick S D, Greenstein S, Zimmerberg B

出版信息

Science. 1972 Aug 11;177(4048):534-5. doi: 10.1126/science.177.4048.534.

DOI:10.1126/science.177.4048.534

Abstract

Rats with bilateral lateral hypothalamic lesions die of starvation in approximately 7 days after surgery. Rats that were treated with alpha-methyl-p-tyrosine for 3 days prior to lateral hypothalamic surgery spontaneously eat, drink, and gain weight after surgery. These data suggest that recovery of function after lateral hypothalamic damage involves denervation supersensitivity.

摘要

双侧下丘脑外侧损伤的大鼠在手术后约7天死于饥饿。在进行下丘脑外侧手术前3天用α-甲基-对-酪氨酸治疗的大鼠在手术后能自主进食、饮水并增重。这些数据表明，下丘脑外侧损伤后功能的恢复涉及去神经超敏反应。