Chopra S K, Taplin G V, Tashkin D P, Trevor E, Elam D
Thorax. 1979 Aug;34(4):493-500. doi: 10.1136/thx.34.4.493.
The sites of airway obstruction and dilatation after terbutaline administration were studied by inhalation imaging and pulmonary function tests in 12 stable asthmatic patients. Inhaled terbutaline as a therapeutic aerosol decreased airway resistance (Raw) and improved radioaerosol (Ae) images in nine, delta V max50 in three, and xenon (Xe) images in five of 12 subjects, suggesting that its predominant site of action was on major airways. Subcutaneously injected terbutaline improved Raw, delta V max50, and Ae images in 11 and Xe images in eight subjects indicating that it released bronchospasm in the major and minor airways. These findings in asthma suggest that aerosol and Xe imaging procedures are sensitive indicators of large and small airway obstruction respectively.
通过吸入显像和肺功能测试，对12例稳定期哮喘患者在使用特布他林后气道阻塞和扩张的部位进行了研究。吸入作为治疗气雾剂的特布他林可降低气道阻力（Raw），并改善12名受试者中9人的放射性气溶胶（Ae）图像、3人的△V max50以及5人的氙（Xe）图像，这表明其主要作用部位在大气道。皮下注射特布他林可改善11名受试者的Raw、△V max50和Ae图像以及8名受试者的Xe图像，表明它可缓解大、小气道的支气管痉挛。哮喘的这些研究结果表明，气雾剂和Xe显像程序分别是大气道和小气道阻塞的敏感指标。
