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The conversion of methyl-2-acetoxyethyl-2'-chloroethylamine to an acetylcholine-like aziridinium ion and its action on the isolated guinea pig ileum.

作者信息

Hirst M, Jackson C H

出版信息

Can J Physiol Pharmacol. 1972 Aug;50(8):798-808. doi: 10.1139/y72-116.

DOI:10.1139/y72-116
PMID:5053792
Abstract
摘要

相似文献

1
The conversion of methyl-2-acetoxyethyl-2'-chloroethylamine to an acetylcholine-like aziridinium ion and its action on the isolated guinea pig ileum.2-乙酰氧基乙基-2'-氯乙胺转化为类似乙酰胆碱的氮丙啶离子及其对离体豚鼠回肠的作用。
Can J Physiol Pharmacol. 1972 Aug;50(8):798-808. doi: 10.1139/y72-116.
2
Syntheses and pharmacological actions of 2-((2-chloroethyl)methylamino)ethyl acetate and some of its derivatives on the isolated guinea pig ileum.2-((2-氯乙基)甲氨基)乙酸乙酯及其某些衍生物对豚鼠离体回肠的合成与药理作用
J Med Chem. 1972 Nov;15(11):1183-4. doi: 10.1021/jm00281a026.
3
Presynaptic effect of the aziridinium ion of acetylcholine mustard (methyl-2-acetoxyethyl-2'-chloroethylamine) on the phrenic nerve--rat diaphragm preparation.
Can J Physiol Pharmacol. 1975 Apr;53(2):264-72. doi: 10.1139/y75-038.
4
The question of cholinergic antagonism.胆碱能拮抗作用的问题。
Biochem Pharmacol. 1976 Dec 15;25(24):2761-4. doi: 10.1016/0006-2952(76)90273-2.
5
Ethylcholine mustard aziridinium ion (AF64A) impairs cholinergic neuromuscular transmission in the guinea-pig ileum and urinary bladder, and cholinergic neuromodulation in the enteric nervous system of the guinea-pig distal colon.
Gen Pharmacol. 1986;17(5):543-8. doi: 10.1016/0306-3623(86)90090-x.
6
Studies on the muscarinic receptor: pH dependence of the action of some cholinergic drugs on the guinea-pig ileum.
Arch Int Pharmacodyn Ther. 1973 Aug;204(2):306-15.
7
Synthesis and biological activity of some carbocyclic analogs of muscarine.
J Med Chem. 1973 Mar;16(3):235-9. doi: 10.1021/jm00261a015.
8
1,2-disubstituted cyclohexanes as substrates of acetylcholinesterase and muscarinic agents. A re-investigation.
J Pharm Pharmacol. 1970 Mar;22(3):214-21. doi: 10.1111/j.2042-7158.1970.tb08500.x.
9
Synthesis of pyridinium analogues of acetylcholine and their interactions with intestinal muscarinic receptors.乙酰胆碱吡啶类似物的合成及其与肠道毒蕈碱受体的相互作用。
J Med Chem. 1979 Feb;22(2):177-80. doi: 10.1021/jm00188a010.
10
Relationships between chemical structure and affinity for postganglionic acetylcholine receptors of the guinea-pig ileum.豚鼠回肠化学结构与节后乙酰胆碱受体亲和力之间的关系。
Br J Pharmacol. 1974 May;51(1):81-93. doi: 10.1111/j.1476-5381.1974.tb09635.x.

引用本文的文献

1
Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor.使用乙酰胆碱氮芥研究M(2)毒蕈碱受体的变构相互作用。
J Pharmacol Exp Ther. 2008 Nov;327(2):518-28. doi: 10.1124/jpet.108.141234. Epub 2008 Aug 5.
2
Proceedings: The binding affinity of an alkylating muscarinic agonist: acetylcholine mustard.论文集：一种烷基化毒蕈碱激动剂：乙酰胆碱芥子气的结合亲和力。
Br J Pharmacol. 1974 Mar;50(3):463P-464P.
3
Interaction of benzilylcholine mustard, benzilylcholine and lachesine with the histamine receptor in the longitudinal muscle of guinea-pig ileum.
苯甲酰胆碱氮芥、苯甲酰胆碱和拉切辛与豚鼠回肠纵肌中组胺受体的相互作用。
Br J Pharmacol. 1973 May;48(1):148-55. doi: 10.1111/j.1476-5381.1973.tb08233.x.
4
Affinity-labelling of the muscarinic receptor of the guinea-pig illeum.豚鼠回肠毒蕈碱受体的亲和标记
Naunyn Schmiedebergs Arch Pharmacol. 1975;289(3):237-49. doi: 10.1007/BF00499978.
5
The irreversible binding of acetylcholine mustard to muscarinic receptors in intestinal smooth muscle of the guinea-pig.乙酰胆碱芥子气与豚鼠肠道平滑肌中毒蕈碱受体的不可逆结合。
Br J Pharmacol. 1975 Mar;53(3):363-70. doi: 10.1111/j.1476-5381.1975.tb07372.x.