分泌型免疫球蛋白A对细菌黏附的抑制作用：一种抗原清除机制。

Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal.

作者信息

Williams R C, Gibbons R J

出版信息

Science. 1972 Aug 25;177(4050):697-9. doi: 10.1126/science.177.4050.697.

DOI:10.1126/science.177.4050.697

Abstract

Preparations of secretory iminunoglobuilin A (S-IgA) isolated from human parotid fluid specifically inhibited the adherence of Streptococcus strains to epithelial cells. Since bacterial adherence is a prerequisite for colonization of mucous surfaces. S-IgA-mediated inhibition of adherence would limit bacterial colonization. This mechanism can explain how secretory immunoglobulins function in the disposal of bacterial antigens.

摘要

从人腮腺液中分离出的分泌型免疫球蛋白A（S-IgA）制剂能特异性抑制链球菌菌株对上皮细胞的黏附。由于细菌黏附是黏液表面定植的先决条件，S-IgA介导的黏附抑制作用会限制细菌定植。这一机制可以解释分泌型免疫球蛋白在处理细菌抗原中的作用方式。