Mehta P, Mehta J
Stroke. 1979 Jul-Aug;10(4):464-6. doi: 10.1161/01.str.10.4.464.
In vivo circulating platelet aggregates (CPA) were evaluated in 18 patients aged 6 to 17 years with sickle cell disease and in 11 age and sex matched normal subjects. Twelve patients with sickle cell disease were in steady state and 6 had vaso-occlusive crises. CPA in patients in steady state were similar to those in normal subjects (mean 6 +/- 1% compared to 5 +/- 2%, respectively), whereas patients with vaso-occlusive crisis in acute state had significantly higher CPA (mean 39 +/- 8%) than patients in steady state or normal control individuals (both p less than 0.001). CPA decreased in patients with vaso-occlusive crisis (mean 11 +/- 4%) on the tenth day, in association with clinical improvement. This study suggests that in vivo platelet aggregate formation activity, although normal in sickle cell disease patients in steady state, is significantly increased in patients with vaso-occlusive crises.
对18例6至17岁的镰状细胞病患者以及11名年龄和性别匹配的正常受试者的体内循环血小板聚集体（CPA）进行了评估。12例镰状细胞病患者处于稳定状态，6例发生血管闭塞性危机。处于稳定状态的患者的CPA与正常受试者相似（分别为平均6±1%和5±2%），而处于急性血管闭塞性危机状态的患者的CPA显著高于处于稳定状态的患者或正常对照个体（均p<0.001）。血管闭塞性危机患者在第10天CPA下降（平均11±4%），同时临床症状改善。本研究表明，体内血小板聚集体形成活性在镰状细胞病稳定状态患者中虽正常，但在血管闭塞性危机患者中显著增加。
