Amin Manik A, Amin Amit P, Kulkarni Hemant R
Lata Medical Research Foundation, Nagpur, India.
Ann Hematol. 2004 Jun;83(6):331-5. doi: 10.1007/s00277-003-0833-8. Epub 2004 Mar 30.
Considering the multigenic and multifactorial nature of the disease, we argue that a generalized bone marrow hyperplasia-and not merely erythroid hyperplasia-will occur in sickle cell disease. Consequently, we expect the hematological parameters to depict erythroid, myeloid as well as megakaryocyte hyperplasia. In the light of this expectation, we hypothesized that platelet distribution width (PDW) will increase in sickle cell disease. Here, we report the results from a cross-sectional study of 216 children admitted with complaints suggestive of vaso-occlusive crisis. We observed a strong association between PDW and sickle cell disease as compared to children who had HbAA genotype. Our findings bridge previous inconsistencies relating to the role of platelets in sickle cell disease. Implications of this finding are discussed.
考虑到该疾病的多基因和多因素性质，我们认为镰状细胞病会出现全身性骨髓增生，而不仅仅是红系增生。因此，我们预计血液学参数将显示红系、髓系以及巨核细胞增生。鉴于这一预期，我们假设镰状细胞病患者的血小板分布宽度（PDW）会增加。在此，我们报告了一项对216名因血管闭塞性危象症状入院儿童的横断面研究结果。与HbAA基因型儿童相比，我们观察到PDW与镰状细胞病之间存在密切关联。我们的研究结果弥合了先前关于血小板在镰状细胞病中作用的不一致之处。本文讨论了这一发现的意义。
