Kaste M, Ramsay M
Stroke. 1979 Sep-Oct;10(5):519-22. doi: 10.1161/01.str.10.5.519.
The effects of intravenous tranexamic acid were compared with placebo in 64 patients with subarachnoid hemorrhage. A double-blind procedure was used. One gram of tranexamic acid was given intravenously every 4 hours up to the time of operation on an intracranial arterial aneurysm or for up to 21 days after the first bleeding if operative treatment was not feasible. There were no differences in re-bleeds, morbidity or mortality between the tranexamic and placebo-treated groups. No thromboembolic complications were noted in either group. Our results do not support the use of tranexamic acid in subarachnoid hemorrhage in daily doses of 6 g.
在64例蛛网膜下腔出血患者中，对比了静脉注射氨甲环酸与安慰剂的效果。采用双盲程序。每4小时静脉注射1克氨甲环酸，直至进行颅内动脉瘤手术时；若无法进行手术治疗，则在首次出血后最多使用21天。氨甲环酸治疗组和安慰剂治疗组在再出血、发病率或死亡率方面无差异。两组均未观察到血栓栓塞并发症。我们的研究结果不支持每日剂量为6克的氨甲环酸用于蛛网膜下腔出血的治疗。
