Stähler E, Neumann H O, Niethammer K M
Arch Gynakol. 1976 Mar 5;220(3):199-208. doi: 10.1007/BF00667748.
Tests were carried out on the influence of alloxan-induced diabetes mellitus on the metabolism and the ultrastructure of ovaries of juvenile rats. The diabetes mellitus caused the following changes in the metabolism: reduction in the concentration of ATP and NADPH, increase in the lactate/pyruvate quotient to above 40, reduction in the ATP/ADP quotient to below 1, reduction in the level of activity of the hydrogen-conveying enzymes G-6-P-dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase, increase in the level of activity of the alkaline phosphatase, reduction of the protein content. Ultrastructure: almost complete disappearance of the rough endoplasmic reticulum, shrinkage of the mitochondria, reduction of the cristae and condensation of the matrix. The smooth endoplasmic reticulum remains unchanged, the extent of the Golgi-complex is reduced. Easy removal of the lipid deposits.
对四氧嘧啶诱导的糖尿病对幼年大鼠卵巢代谢和超微结构的影响进行了测试。糖尿病在代谢方面引起了以下变化：ATP和NADPH浓度降低，乳酸/丙酮酸商增加至40以上，ATP/ADP商降低至1以下，氢传递酶G-6-P-脱氢酶、异柠檬酸脱氢酶和苹果酸脱氢酶的活性水平降低，碱性磷酸酶的活性水平增加，蛋白质含量降低。超微结构：粗面内质网几乎完全消失，线粒体收缩，嵴减少，基质浓缩。滑面内质网保持不变，高尔基体复合体范围缩小。脂质沉积物易于去除。
