麻风病中的血清非典型假性胆碱酯酶和遗传因素。
Serum atypical pseudocholinesterase and genetic factors in leprosy.
作者信息
Thomas M, Job C K
出版信息
Br Med J. 1972 Aug 12;3(5823):390-1. doi: 10.1136/bmj.3.5823.390.
The levels of pseudocholinesterase and its nature were studied in 390 leprosy patients and 343 control subjects. The levels of the enzyme in both leprosy patients and normal controls were comparable. The study of the nature of the enzyme by determining its dibucaine number showed that a statistically significant number of lepromatous patients had the atypical variety of the enzyme compared with normal controls or tuberculoid patients. Since the presence of the atypical variety of the enzyme is genetically determined it is suggested that genetic factors play an important part in deciding susceptibility to lepromatous leprosy.
对390例麻风患者和343例对照者的假胆碱酯酶水平及其性质进行了研究。麻风患者和正常对照者的酶水平相当。通过测定其地布卡因值对该酶的性质进行研究表明，与正常对照者或结核样型患者相比，瘤型患者中具有非典型酶型的人数具有统计学意义。由于非典型酶型的存在是由遗传决定的，因此提示遗传因素在决定对瘤型麻风的易感性方面起重要作用。
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