几种三环类抗抑郁药对大鼠离体胃底条抗胆碱能作用的定量研究。
A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.
作者信息
Atkinson J, Ladinsky H
出版信息
Br J Pharmacol. 1972 Jul;45(3):519-24. doi: 10.1111/j.1476-5381.1972.tb08109.x.
Abstract
- Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants.2. The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine.3. Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.
摘要
研究了几种三环类抗抑郁药对氯化氨甲酰胆碱作用于大鼠离体胃底的拮抗作用。
这些化合物的抗胆碱能效力顺序为：GP 45437＞阿米替林＞普罗替林＞去甲丙咪嗪＞奥匹哌醇。所有拮抗剂的效果均不如阿托品。
进行了统计分析，以确定竞争性拮抗理论是否符合所获得的数据。
相似文献
1
A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.几种三环类抗抑郁药对大鼠离体胃底条抗胆碱能作用的定量研究。
Br J Pharmacol. 1972 Jul;45(3):519-24. doi: 10.1111/j.1476-5381.1972.tb08109.x.
2
Delayed oxyphenylbutazone absorption by some tricyclic compounds in the rat.大鼠体内某些三环化合物对羟基保泰松吸收的延迟作用
Arch Int Pharmacodyn Ther. 1971 Aug;192(2):265-70.
3
Central anticholinergic activity of imipramine and allied drugs.丙咪嗪及相关药物的中枢抗胆碱能活性。
Can J Physiol Pharmacol. 1967 Mar;45(2):353-5. doi: 10.1139/y67-039.
4
Studies on the putative anticholinergic effects of desmethylimipramine.去甲丙咪嗪假定抗胆碱能作用的研究。
Arch Int Pharmacodyn Ther. 1980 Jan;243(1):37-47.
5
The peripheral anticholinergic activity of tricyclic antidepressants: comparison of amitriptyline and desipramine in human volunteers.三环类抗抑郁药的外周抗胆碱能活性：阿米替林与地昔帕明在人类志愿者中的比较。
Br J Psychiatry. 1980 Nov;137:433-9. doi: 10.1192/bjp.137.5.433.
6
Cardiac effects of antidepressants.抗抑郁药对心脏的影响。
Jpn J Pharmacol. 1972 Jun;22(3):283-93. doi: 10.1254/jjp.22.283.
7
Atropine blockade of cholinergic drugs on rabbit stomach muscle.阿托品对胆碱能药物在兔胃肌上的阻断作用。
Can J Physiol Pharmacol. 1978 Oct;56(5):873-6. doi: 10.1139/y78-136.
8
Anticholinergic activity of two tricyclic antidepressants.两种三环类抗抑郁药的抗胆碱能活性。
Am J Psychiatry. 1978 Jun;135(6):722-4. doi: 10.1176/ajp.135.6.722.
9
Clinical significance of anticholinergic effects of imipramine-like drugs.丙咪嗪类药物抗胆碱能效应的临床意义。
Am J Psychiatry. 1969 May;125(11):1600-2. doi: 10.1176/ajp.125.11.1600.
10
The reversal of clonidine-induced hypotension by protriptyline and desipramine.丙咪嗪和去甲丙咪嗪对可乐定所致低血压的逆转作用。
Pharmacology. 1976;14(3):227-31. doi: 10.1159/000136599.
引用本文的文献
1
Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.抗抑郁药对人脑海马胆碱能乙酰胆碱受体的拮抗作用。
Br J Pharmacol. 1983 Jan;78(1):97-102.
2
The effect of some antidepressants on prejunctional muscarinic receptors on the sympathetic nerves of the isolated rabbit ear artery.某些抗抑郁药对离体兔耳动脉交感神经节前毒蕈碱受体的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):14-9. doi: 10.1007/BF00499065.
3
The effects of several muscarinic antagonists on pre- and postsynaptic receptors in the isolated rabbit heart.几种毒蕈碱拮抗剂对离体兔心脏突触前和突触后受体的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb;316(1):31-7. doi: 10.1007/BF00507223.
4
Proceedings: The dual action of tricyclic antidepressant drugs on responses of single cortical neurones to acetylcholine.论文集：三环类抗抑郁药对单个皮质神经元对乙酰胆碱反应的双重作用。
Br J Pharmacol. 1973 Sep;49(1):173P-174P.
5
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.三环类抗抑郁药地昔帕明、多塞平和茚满二氮䓬对离体灌注兔心脏的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1974;284(3):215-32. doi: 10.1007/BF00500343.
6
Comparison of the effects of binodaline and amitriptyline on peripheral autonomic functions in healthy volunteers.健康志愿者中比诺达林与阿米替林对外周自主神经功能影响的比较。
Br J Clin Pharmacol. 1985 Mar;19(3):295-300. doi: 10.1111/j.1365-2125.1985.tb02646.x.
7
The effect of tricyclic antidepressants on cholinergic responses of single cortical neurones.三环类抗抑郁药对单个皮层神经元胆碱能反应的影响。
Br J Pharmacol. 1975 Jan;53(1):29-36. doi: 10.1111/j.1476-5381.1975.tb07326.x.
8
[The effect of coffee and coffee components on the stomach muscle].[咖啡及其成分对胃肌的影响]
Z Ernahrungswiss. 1976 Jun;15(2):156-63. doi: 10.1007/BF02018436.
9
Structure-activity relationships for the anticholinoceptor action of tricyclic antidepressants.三环类抗抑郁药抗胆碱受体作用的构效关系。
Br J Pharmacol. 1978 Apr;62(4):567-71. doi: 10.1111/j.1476-5381.1978.tb07763.x.
本文引用的文献
1
Quantitative studies of antagonists for 5-hydroxytryptamine.5-羟色胺拮抗剂的定量研究。
Q J Exp Physiol Cogn Med Sci. 1955 Jan;40(1):49-74. doi: 10.1113/expphysiol.1955.sp001097.
2
CLINICAL PHARMACOLOGY OF IMIPRAMINE AND RELATED ANTIDEPRESSANT COMPOUNDS.丙咪嗪及相关抗抑郁化合物的临床药理学
Pharmacol Rev. 1965 Jun;17:101-41.
3
ACETYLCHOLINE IN ADRENERGIC TRANSMISSION.肾上腺素能传递中的乙酰胆碱
Annu Rev Pharmacol. 1965;5:163-82. doi: 10.1146/annurev.pa.05.040165.001115.
4
[COMPARATIVE STUDIES ON ALTERATION OF VEGETATIVE FUNCTIONS BY PSYCHOPHARMACOLOGICAL AGENTS IN ACUTE ANIMAL EXPERIMENTS].
Arzneimittelforschung. 1965 Feb;15:117-25.
5
[COMPARATIVE PHARMACOLOGICAL INVESTIGATIONS WITH TOFRANIL, PERTOFRAN AND INSIDON].[多虑平、安拿芬尼与因赛顿的比较药理学研究]
Arch Int Pharmacodyn Ther. 1964 Apr 1;148:560-96.
6
Cholinergic blockade as an approach to the development of new psychotropic agents.
Ann N Y Acad Sci. 1962 Jan 13;96:251-62. doi: 10.1111/j.1749-6632.1962.tb50120.x.
7
Carbamylation of acetvlcholinesterase.乙酰胆碱酯酶的氨甲酰化
J Biol Chem. 1960 Aug;235:2312-5.
8
[On the pharmacology of tofranil (N-(3-dimethylaminopropyl)-iminodibenzyl hydrochloride].关于多虑平（N-（3-二甲氨基丙基）-亚氨基二苄基盐酸盐）的药理学
Arch Int Pharmacodyn Ther. 1959 Jul 1;120:450-89.
9
The physiological role of acetyl-cholinesterase (AChE) in sympathetic ganglia.乙酰胆碱酯酶（AChE）在交感神经节中的生理作用。
J Pharmacol Exp Ther. 1961 Aug;133:223-40.
10
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
Zotero 插件