Couch J R, Hassanein R S
Arch Neurol. 1979 Nov;36(11):695-9. doi: 10.1001/archneur.1979.00500470065013.
In a controlled trial of amitriptyline hydrochloride in migraine prophylaxis, 100 patients received placebo for a four-week baseline period and then were randomized in double-blind fashion to therapy with amitriptyline (47 subjects) or placebo (53 subjects) for another four to eight weeks. Subjects received up to four 25-mg tablets of amitriptyline hydrochloride or identical placebo per day. Comparing the first and second four-week periods for each patient, the conditions of 55.3% of amitriptyline subjects as opposed to 34.0% of placebo subjects were greater than or equal to 50% improved and the difference between amitriptyline and placebo response rates was significant (P less than .05). Nondepressed subjects with severe migraine and depressed subjects with less severe migraine responded best to amitriptyline, whereas depressed subjects with severe migraine had little headache relief. Amitritryline is an effective antimigraine agent and the antimigraine effect seems relatively independent of antidepressant activity.
在一项关于盐酸阿米替林预防偏头痛的对照试验中，100名患者在为期四周的基线期接受安慰剂治疗，然后以双盲方式随机分为接受阿米替林治疗（47名受试者）或安慰剂治疗（53名受试者），持续另外四至八周。受试者每天最多服用四片25毫克的盐酸阿米替林片剂或相同的安慰剂。比较每位患者的第一个和第二个四周治疗期，55.3%接受阿米替林治疗的受试者病情改善程度大于或等于50%，而接受安慰剂治疗的受试者这一比例为34.0%，阿米替林组与安慰剂组的有效率差异具有统计学意义（P<0.05）。重度偏头痛的非抑郁受试者和轻度偏头痛的抑郁受试者对阿米替林反应最佳，而重度偏头痛的抑郁受试者头痛缓解效果不佳。阿米替林是一种有效的抗偏头痛药物，其抗偏头痛作用似乎相对独立于抗抑郁活性。
