Stockard J E, Stockard J J, Westmoreland B F, Corfits J L
Arch Neurol. 1979 Dec;36(13):823-31. doi: 10.1001/archneur.1979.00500490037006.
Brainstem auditory-evoked responses (BAERs) were elicited from 64 neurologically and audiometrically normal adults and 77 normal, full-term neonates with broadband rarefaction or condensation clicks at sensation levels (hearing levels in neonates) of 30 to 70 dB and at rates of ten and 80 clicks per second. In addition to the known effects of rate, previously unrecognized effects of acoustic phase and stimulus intensity on BAER interpeak latencies (IPLs), and an interaction of all three stimulus parameters, were found. Stimulus characteristics, age, and sex can account for much of the inter- and intrasubject variability of BAER IPLs and morphology. The BAER effects of many of these variables and their interactions have not been appreciated in clinical applications of BAER. Recognition and control of such reducible, methodological sources of BAER variability will enhance the sensitivity and specificity of the test in neurologic diagnosis.
对64名神经学和听力检查均正常的成年人以及77名正常足月新生儿进行脑干听觉诱发电位（BAER）检测，采用宽带疏波或密波短声，刺激强度（新生儿为听力级）为30至70分贝，刺激率分别为每秒10次和80次。除了已知的刺激率效应外，还发现了声学相位和刺激强度对BAER峰间潜伏期（IPL）有此前未被认识到的效应，以及这三个刺激参数之间的相互作用。刺激特性、年龄和性别可解释BAER IPL和波形在个体间和个体内的大部分变异性。在BAER的临床应用中，许多这些变量及其相互作用的BAER效应尚未得到重视。识别并控制这种可减少的、方法学上导致BAER变异性的来源，将提高该检测在神经学诊断中的敏感性和特异性。
