高剂量美托拉宗治疗慢性肾衰竭
High dosage metolazone in chronic renal failure.
作者信息
Dargie H J, Allison M E, Kennedy A C, Gray M J
出版信息
Br Med J. 1972 Oct 28;4(5834):196-8. doi: 10.1136/bmj.4.5834.196.
Abstract
Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7.5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1.2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.
摘要
美托拉宗是一种改良的喹唑啉磺酰胺，剂量在4至7.5毫克之间时，对肾功能正常的人是一种有效的利尿剂。14例非水肿性稳定慢性肾衰竭患者（肌酐清除率在1.2至12毫升/分钟之间）接受了剂量为20至150毫克的美托拉宗治疗。尿量和钠排泄量显著增加，自由水清除率提高，钾排泄量有小幅但显著的增加。未观察到副作用。
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