• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols.

作者信息

Ortiz de Montellano P R, Beck J P, Ourisson G

出版信息

Biochem Biophys Res Commun. 1979 Oct 12;90(3):897-903. doi: 10.1016/0006-291x(79)91912-0.

DOI:10.1016/0006-291x(79)91912-0
PMID:508352
Abstract
摘要

相似文献

1
Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols.培养的肝癌细胞中甾醇生物合成与裂解的调控：羟基甾醇对羊毛甾醇去甲基化的抑制作用。
Biochem Biophys Res Commun. 1979 Oct 12;90(3):897-903. doi: 10.1016/0006-291x(79)91912-0.
2
Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol.肝脏胆固醇生物合成的调节。细胞色素P-450抑制剂对羊毛甾醇氧化甾醇产物形成和代谢的影响。
Biochem J. 1989 Dec 1;264(2):495-502. doi: 10.1042/bj2640495.
3
In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity.3β-羟基羊毛甾-8-烯-32-醛在肝细胞培养物中的原位积累。一种3-羟基-3-甲基戊二酰辅酶A还原酶活性的假定调节剂。
J Biol Chem. 1987 Sep 5;262(25):12261-8.
4
Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation.唑类抗真菌药对3-羟基-3-甲基戊二酰辅酶A还原酶的调节作用需要羊毛甾醇去甲基化，但不需要24,25-环氧羊毛甾醇的形成。
J Biol Chem. 1987 Sep 5;262(25):12254-60.
5
Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells.
Biochem Biophys Res Commun. 1984 Apr 30;120(2):657-64. doi: 10.1016/0006-291x(84)91306-8.
6
[Activities of 3-hydroxyl-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and the rate of mevalonic acid, squalene, sterol and fatty acid biosynthesis from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: effects of Triton WR 1339, starvation and cholesterol diet].[大鼠肝脏中3-羟基-3-甲基戊二酰辅酶A还原酶和乙酰辅酶A羧化酶的活性以及[1-¹⁴C]乙酰辅酶A和[2-¹⁴C]丙二酰辅酶A生成甲羟戊酸、角鲨烯、固醇和脂肪酸的生物合成速率：曲拉通WR 1339、饥饿和胆固醇饮食的影响]
Biokhimiia. 1981 Feb;46(2):296-305.
7
Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites.角鲨烯、羊毛甾醇、去氢胆甾醇和胆固醇与脑和肝脏105,000g上清液组分中蛋白质的结合：特异性结合位点的证据。
Lipids. 1976 Sep;11(9):645-51. doi: 10.1007/BF02532881.
8
A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system.在无肿瘤细胞的系统中，3-羟基-3-甲基戊二酰辅酶A还原酶的细胞含量不协调增加会导致对胆固醇生成的限速控制丧失。
Biochem J. 1989 Mar 1;258(2):421-5. doi: 10.1042/bj2580421.
9
Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells.Hep-G2细胞中低密度脂蛋白受体活性的非固醇依赖性调节证据。
Biochem J. 1991 Oct 1;279 ( Pt 1)(Pt 1):175-87. doi: 10.1042/bj2790175.
10
Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase.从羊毛甾醇合成胆固醇：大鼠肝脏甾醇8-异构酶的调控与纯化
J Biochem. 1995 Apr;117(4):819-23. doi: 10.1093/oxfordjournals.jbchem.a124781.

引用本文的文献

1
Inhibition by ketoconazole of mitogen-induced DNA synthesis and cholesterol biosynthesis in lymphocytes.酮康唑对淋巴细胞中丝裂原诱导的DNA合成和胆固醇生物合成的抑制作用。
Antimicrob Agents Chemother. 1983 Oct;24(4):478-85. doi: 10.1128/AAC.24.4.478.
2
Differential sensitivity of astrocyte primary cultures and derived spontaneous transformed cell lines to 7 beta-hydroxycholesterol: effect on plasma membrane lipid composition and fluidity, and on cell surface protein expression.星形胶质细胞原代培养物和衍生的自发转化细胞系对7β-羟基胆固醇的差异敏感性：对质膜脂质组成和流动性以及细胞表面蛋白表达的影响。
Mol Cell Biochem. 1991 Feb 27;101(1):11-22. doi: 10.1007/BF00238433.