Knight M, Lennox S
Thorax. 1972 Sep;27(5):577-82. doi: 10.1136/thx.27.5.577.
Surgical closure of an atrial septal defect was performed on 104 patients over the age of 40 at the Brompton Hospital. The hospital mortality was 9·6%, reducing to 2·7% in the last six years. There were five late deaths. A moderate increase in preoperative pulmonary artery systolic pressure did not influence mortality. Twenty-five per cent of patients in preoperative atrial fibrillation have been maintained in sinus rhythm an average of five years following operation. Seven per cent of patients in sinus rhythm preoperatively left hospital in atrial fibrillation. Another 7% developed atrial fibrillation an average of seven years after operation. At late follow-up 75 patients were symptom-free and leading normal lives. It is concluded that patients in this age group with atrial septal defect benefit from surgical closure of the defect.
在布朗普顿医院，对104名40岁以上的患者实施了房间隔缺损的外科闭合手术。医院死亡率为9.6%，在过去六年中降至2.7%。有5例晚期死亡。术前肺动脉收缩压适度升高并不影响死亡率。术前处于心房颤动的患者中有25%在术后平均五年维持窦性心律。术前处于窦性心律的患者中有7%出院时为心房颤动。另有7%的患者在术后平均七年发生心房颤动。在晚期随访中，75名患者无症状，过着正常生活。得出的结论是，这个年龄组患有房间隔缺损的患者可从缺损的外科闭合中获益。
