肾脏和骨骼的降钙素受体。
Calcitonin receptors of kidney and bone.
作者信息
Marx S J, Woodward C J, Aurbach G D
出版信息
Science. 1972 Dec 1;178(4064):999-1001. doi: 10.1126/science.178.4064.999.
PMID:5084670
Abstract
Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon calcitonin accounts in part for the high biological potency in vivo of salmon calcitonin.
摘要
通过腺苷酸环化酶激活所确定的降钙素受体，其在肾脏各区域的分布与甲状旁腺激素或抗利尿激素受体的分布不同。竞争性结合研究表明，肾脏和骨骼中的降钙素受体相似，并且它们对鲑鱼降钙素的高表观亲和力部分解释了鲑鱼降钙素在体内的高生物活性。
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