细胞色素P-450在胆固醇生物合成及分解代谢中的作用。
The role of cytochrome P-450 in cholesterol biogenesis and catabolism.
作者信息
Atkin S D, Palmer E D, English P D, Morgan B, Cawthorne M A, Green J
出版信息
Biochem J. 1972 Jun;128(2):237-42. doi: 10.1042/bj1280237.
Abstract
- Adjuvant-induced arthritis in rats is accompanied by a loss of activity of the drug-metabolizing enzyme system and a decrease in hepatic cytochrome P-450. 2. Arthritic rats have normal serum and liver cholesterol concentrations. 3. The rate of biogenesis of cholesterol in vivo and in vitro from either [(14)C]acetate or [(14)C]mevalonate in arthritic rats was the same as or greater than that found in control rats. 4. Treatment of rats with carbon disulphide (1ml/kg) resulted in a loss of drug-metabolizing-enzyme activity and increased cholesterol biogenesis. 5. The activity of cholesterol 7alpha-hydroxylase in adjuvant-induced arthritic rats did not differ significantly from that in control rats. 6. Rats fed with cholestyramine had an elevated hepatic cholesterol 7alpha-hydroxylase activity, but neither the concentration of cytochrome P-450 nor the activity of the drug-hydroxylating enzyme, aminopyrine demethylase, was affected. 7. The relationships between drug hydroxylation and cholesterol metabolism are discussed.
摘要
- 佐剂诱导的大鼠关节炎伴有药物代谢酶系统活性丧失和肝细胞色素P - 450减少。2. 关节炎大鼠的血清和肝脏胆固醇浓度正常。3. 关节炎大鼠体内和体外由[（14）C]乙酸盐或[（14）C]甲羟戊酸生成胆固醇的速率与对照大鼠相同或更高。4. 用二硫化碳（1ml/kg）处理大鼠导致药物代谢酶活性丧失并增加胆固醇生物合成。5. 佐剂诱导的关节炎大鼠中胆固醇7α - 羟化酶的活性与对照大鼠无显著差异。6. 喂食消胆胺的大鼠肝脏胆固醇7α - 羟化酶活性升高，但细胞色素P - 450浓度和药物羟化酶氨基比林脱甲基酶的活性均未受影响。7. 讨论了药物羟化与胆固醇代谢之间的关系。
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