Reddy J K, Qureshi S A
Br J Cancer. 1979 Sep;40(3):476-82. doi: 10.1038/bjc.1979.203.
Ethyl-alpha-p-chlorophenoxyisobutyrate), a hypolipidaemic drug which induces hepatomegaly and proliferation of peroxisomes in liver cells of rats and mice, was fed to 15 male F344 rats at a dietary concentration of 0.5% (v/w) for up to 28 months. Hepatocellular carcinomas developed in 10/11 (91%) rats killed between 24 and 28 months. Other tumours included carcinoma of the pancreas (2 rats), leiomyoma of the small intestine (1 rat) and a large dermatofibrosarcoma (1 rat). Clofibrate is the third hypolipidaemic peroxisome proliferator demonstrated to be hepatocarcinogenic in rats. These studies suggest that hypolipidaemic agents which are capable of producing a sustained hepatomegalic and peroxisome-proliferative effect also induce liver tumours.
α-对氯苯氧异丁酸乙酯是一种降血脂药物，可导致大鼠和小鼠肝细胞肝肿大和过氧化物酶体增殖。将其以0.5%（体积/重量）的膳食浓度喂给15只雄性F344大鼠，持续28个月。在24至28个月处死的11只大鼠中有10只（91%）发生了肝细胞癌。其他肿瘤包括胰腺癌（2只大鼠）、小肠平滑肌瘤（1只大鼠）和一个大的皮肤纤维肉瘤（1只大鼠）。氯贝丁酯是第三种被证明对大鼠有致癌性的降血脂过氧化物酶体增殖剂。这些研究表明，能够产生持续肝肿大和过氧化物酶体增殖作用的降血脂药物也会诱发肝脏肿瘤。
