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庆大霉素在人房水中的渗透与衰减

Gentamicin penetration and decay in the human aqueous.

作者信息

Hillman J S, Jacobs S I, Garnett A J, Kheskani M B

出版信息

Br J Ophthalmol. 1979 Nov;63(11):794-6. doi: 10.1136/bjo.63.11.794.

DOI:10.1136/bjo.63.11.794
PMID:508697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043622/
Abstract

The penetration of gentamicin into human aqueous was measured after intensive drops or subconjunctival injection of the antibiotic. The drop regimen proved ineffective in producing a therapeutically effective level. After a single 40 mg subconjunctival injection an effective concentration was achieved in 2 hours and maintained for 24 hours. The significance of these findings is discussed with respect to therapeutic implications.

摘要

在频繁滴眼或结膜下注射庆大霉素后，测定了庆大霉素在人房水中的渗透情况。滴眼方案被证明无法产生治疗有效的水平。单次结膜下注射40毫克后，在2小时内达到有效浓度，并维持24小时。就治疗意义对这些发现的重要性进行了讨论。

相似文献

1
Gentamicin penetration and decay in the human aqueous.庆大霉素在人房水中的渗透与衰减
Br J Ophthalmol. 1979 Nov;63(11):794-6. doi: 10.1136/bjo.63.11.794.
2
[Aqueous humor levels of gentamicin after parenteral, subconjunctival and topical administration (aithor's transl)].
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3
Penetration and systemic absorption of gentamicin after subconjunctival injection.结膜下注射后庆大霉素的渗透及全身吸收情况
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4
Penetration of gentamicin into the aphakic eye.
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Penetration of gentamicin into the aqueous humor of human eyes.
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Gentamicin penetration in human aqueous after subconjunctival injection.结膜下注射后庆大霉素在人房水中的渗透情况。
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引用本文的文献

1
Comparative review of topical ophthalmic antibacterial preparations.局部用眼科抗菌制剂的比较综述
Drugs. 2001;61(2):175-85. doi: 10.2165/00003495-200161020-00003.
2
Sodium hyaluronate 0.25% used as a vehicle increases the bioavailability of topically administered gentamicin.用作赋形剂的0.25%透明质酸钠可提高局部应用庆大霉素的生物利用度。
Graefes Arch Clin Exp Ophthalmol. 1993 Mar;231(3):157-61. doi: 10.1007/BF00920939.

本文引用的文献

1
Subconjunctival gentamicin.结膜下注射庆大霉素。
Br J Ophthalmol. 1971 Jul;55(7):478-80. doi: 10.1136/bjo.55.7.478.
2
Penicillin combined with gentamicin or streptomycin: synergism against enterococci.青霉素与庆大霉素或链霉素联合使用：对肠球菌有协同作用。
J Infect Dis. 1971 Dec;124(6):581-6. doi: 10.1093/infdis/124.6.581.
3
Penetration and systemic absorption of gentamicin after subconjunctival injection.结膜下注射后庆大霉素的渗透及全身吸收情况
Br J Ophthalmol. 1972 Aug;56(8):609-12. doi: 10.1136/bjo.56.8.609.
4
Penetration of gentamicin into the aqueous humor of human eyes.
Am J Ophthalmol. 1970 Mar;69(3):481-3. doi: 10.1016/0002-9394(70)92286-5.
5
Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin.培养基成分对铜绿假单胞菌对庆大霉素表观敏感性的影响。
J Clin Pathol. 1969 Sep;22(5):534-8. doi: 10.1136/jcp.22.5.534.
6
Penetration of antistaphylococcal antibiotics into the human eye.
Am J Ophthalmol. 1974 Apr;77(4):589-92. doi: 10.1016/0002-9394(74)90476-0.
7
Ocular penetration of topically applied gentamicin.
Arch Ophthalmol. 1975 May;93(5):371-8. doi: 10.1001/archopht.1975.01010020383014.
8
Intraocular penetration of gentamicin after subconjunctibal and retrobulbar injection .
Am J Ophthalmol. 1978 Apr;85(4):541-7. doi: 10.1016/s0002-9394(14)75252-3.