Carey M C, Wu S F, Watkins J B
Biochim Biophys Acta. 1979 Oct 26;575(1):16-26. doi: 10.1016/0005-2760(79)90126-7.
Physical-chemical properties of the major sulfated monohydroxy bile salts of man are described. In general, the sulfates are significantly more water-soluble than the non-sulfated species as a result of lower critical micellar temperatures, high aqueous monomeric solubilities and critical micellar concentrations. Nevertheless, at 37 degrees C the disodium salt of glycolithocholate sulfate, the major monohydroxy bile salt of man is not more soluble than its non-sulfated form. Since aqueous solubility correlates inversely with the cholestatic potential of bile salts, our results suggest that this sulfate may be potentially hepatoxic. Micellar solubility of phosphatidylcholine and cholesterol by the majority of non-sulfated and sulfated monohydroxy bile salts is slight. Nonetheless, phosphatidylcholine is very well solubilized by taurolithocholate sulfate but cholesterol solubility is not increased appreciably. Cholesterol saturation in model bile systems of taurochenodeoxycholate and phosphatidylcholine is impaired by the addition of sulfated lithocholate conjugates but with physiological bile salt compositions this reduction is not significant.
本文描述了人体主要硫酸化单羟基胆汁盐的物理化学性质。一般来说，由于较低的临界胶束温度、较高的单体水溶性和临界胶束浓度，硫酸盐的水溶性明显高于非硫酸化的同类物质。然而，在37摄氏度时，硫酸甘氨石胆酸二钠盐（人体主要的单羟基胆汁盐）的溶解度并不比其非硫酸化形式更高。由于水溶性与胆汁盐的胆汁淤积潜力呈负相关，我们的结果表明这种硫酸盐可能具有潜在的肝毒性。大多数非硫酸化和硫酸化单羟基胆汁盐对磷脂酰胆碱和胆固醇的胶束溶解度很小。尽管如此，硫酸牛磺石胆酸能很好地溶解磷脂酰胆碱，但胆固醇的溶解度没有明显增加。在牛磺鹅去氧胆酸和磷脂酰胆碱的模型胆汁系统中，添加硫酸化石胆酸共轭物会损害胆固醇的饱和状态，但在生理胆汁盐组成情况下，这种降低并不显著。
