Bochenek W J, Rodgers J B
Biochim Biophys Acta. 1979 Oct 26;575(1):57-62. doi: 10.1016/0005-2760(79)90130-9.
The effect of dietary cholesterol on rat intestinal 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) varied depending upon whether animals received the dietary cholesterol with polyunsaturated or saturated fats. When cholesterol was fed with polyunsaturates, the enzyme activity in both the jejunum and ileum was significantly suppressed, whereas only the enzyme in the jejunum was significantly suppressed when cholesterol was given with saturated fats. It is concluded that dietary cholesterol has a negative feedback effect on intestinal cholesterol synthesis.
膳食胆固醇对大鼠肠道3-羟基-3-甲基戊二酰辅酶A还原酶（EC 1.1.1.34）的影响因动物摄入的膳食胆固醇是与多不饱和脂肪还是饱和脂肪一起而有所不同。当胆固醇与多不饱和脂肪酸一起喂食时，空肠和回肠中的酶活性均被显著抑制，而当胆固醇与饱和脂肪一起给予时，只有空肠中的酶被显著抑制。由此得出结论，膳食胆固醇对肠道胆固醇合成具有负反馈作用。
