Boeryd B, Hallgren B, Ställberg G
Br J Exp Pathol. 1971 Jun;52(3):221-30.
2-Methoxyalkyl glycerol ethers isolated from Greenland shark liver oil in a concentration of 0·5 per cent of the diet inhibited metastasis formation from the methylcholanthrene-induced sarcoma MCGI-SS in syngeneic CBA mice. This was shown for spontaneous metastases to the lymph nodes and in one experiment to the lungs and for intravenously induced metastases to the liver. By studying the effect of the compounds not only on tumour growth but also on metastasis formation in different ways it was possible to reveal effects on metastasis formation even at dose levels not affecting the primary tumours.
从格陵兰鲨肝油中分离出的2-甲氧基烷基甘油醚,以饮食的0.5%的浓度存在时,可抑制同基因CBA小鼠中由甲基胆蒽诱导的肉瘤MCGI-SS的转移形成。这在自发转移至淋巴结以及在一项实验中转移至肺部的情况中得到了证实,并且在静脉注射诱导转移至肝脏的情况中也得到了证实。通过以不同方式研究这些化合物不仅对肿瘤生长而且对转移形成的影响,即使在不影响原发性肿瘤的剂量水平下,也有可能揭示其对转移形成的影响。