利用金鱼的翻正反射终点来测量地西泮与乙醇的相互作用以及地西泮与牛血清白蛋白结合的影响。

Use of the overturn end point in goldfish to measure the interaction of diazepam and ethanol and the effects of the binding of diazepam to bovine serum albumin.

作者信息

Giles H G, Kadar G, MacLeod S M, Sellers E M

出版信息

Can J Physiol Pharmacol. 1979 Oct;57(10):1186-8. doi: 10.1139/y79-177.

Abstract

Over the ranges 2.8 X 10(-5) to 8.78 X 10(-5) M diazepam and 4.85 X 10(-2) to 1.22 X 10(-1) M ethanol, addition of the effects of these agents on the overturn end point in goldfish was observed. The addition of bovine serum albumin (1.56 X 10(-5) M) to aqueous solutions of diazepam modifies the diazepam effect by reducing the "free" drug concentrations.

摘要

在2.8×10⁻⁵至8.78×10⁻⁵M地西泮和4.85×10⁻²至1.22×10⁻¹M乙醇的浓度范围内，观察了这些药剂对金鱼翻转终点的联合作用。向地西泮水溶液中添加牛血清白蛋白（1.56×10⁻⁵M）可通过降低“游离”药物浓度来改变地西泮的作用。