Moore W, Hysell D, Hall L, Campbell K, Stara J
Environ Health Perspect. 1975 Apr;10:63-71. doi: 10.1289/ehp.751063.
Preliminary data are given on the LD50 of PdCl2 following different routes of exposure and on the LD50 of PtCl4 following intravenous exposure. The retention, tissue distribution, and excretion of 103Pd and 191Pt in rats was determined following oral, intravenous, intratracheal, and inhalation exposure. The highest retention for both 103Pd and 191Pt was obtained following intravenous dosing, and the lowest retention occurred after oral dosing. Following a single oral dose, almost all of the 103Pd and 191Pt was excreted in the feces due to nonabsorption, whereas after intravenous dosing, similar quantities were excreted in both the urine and feces. Tissues containing the highest concentrations of these metals were the kidney, spleen and liver. Following intravenous dosing of pregnant rats, a small amount of 103Pd and 191Pt was found in the fetuses.
给出了氯化钯经不同暴露途径的半数致死剂量（LD50）以及四氯化铂经静脉暴露的半数致死剂量的初步数据。测定了大鼠经口、静脉、气管内和吸入暴露后103钯和191铂的潴留、组织分布及排泄情况。静脉给药后103钯和191铂的潴留量最高，经口给药后潴留量最低。单次经口给药后，由于未被吸收，几乎所有的103钯和191铂都随粪便排出，而静脉给药后，尿液和粪便中的排出量相近。这些金属浓度最高的组织是肾脏、脾脏和肝脏。给怀孕大鼠静脉给药后，在胎儿体内发现了少量的103钯和191铂。
