Cherry J D, Taylor-Robinson D, Willers H, Stenhouse A C
Thorax. 1971 Jan;26(1):62-7. doi: 10.1136/thx.26.1.62.
Throat and bronchoscopy specimens for mycoplasma isolation studies were collected from 22 patients with chronic bronchitis and 20 patients without chronic bronchitis. Twenty-six of 50 patients attending a chronic bronchitis clinic had throat, nasal, or sputum specimens collected for attempted mycoplasma isolation, and all of these patients had multiple serum samples taken for mycoplasma antibody studies. Mycoplasmas were recovered from throat and bronchoscopy specimens of the chronic bronchitic and non-bronchitic patients with about equal frequency. The concentration of organisms in the bronchoscopy specimens of two patients with chronic bronchitis was greater than in their throat specimens, suggesting downward spread and multiplication of mycoplasmas rather than contamination by passage of the bronchoscope. Eighty-three per cent of the rises in mycoplasma antibody titre in chronic bronchitic patients occurred during or immediately after an acute respiratory illness, and this relationship of rise in antibody titre to acute illness was significantly more frequent than rises in antibody titre not associated with illness. We suggest that mycoplasmas may be present in the bronchi of some patients suffering from chronic bronchitis and that, while such mycoplasma infections are often silent, they may become sufficiently active during infection by other agents to stimulate a mycoplasma antibody response.
为进行支原体分离研究，从22例慢性支气管炎患者和20例无慢性支气管炎患者中采集了咽喉和支气管镜检查标本。在一家慢性支气管炎诊所就诊的50例患者中，有26例采集了咽喉、鼻腔或痰液标本用于尝试分离支原体，并且所有这些患者都采集了多份血清样本用于支原体抗体研究。慢性支气管炎患者和非慢性支气管炎患者的咽喉和支气管镜检查标本中分离出支原体的频率大致相同。两名慢性支气管炎患者支气管镜检查标本中的病原体浓度高于其咽喉标本中的浓度，这表明支原体有向下扩散和增殖，而非支气管镜检查过程中的污染。慢性支气管炎患者中83%的支原体抗体滴度升高发生在急性呼吸道疾病期间或之后不久，并且抗体滴度升高与急性疾病的这种关系明显比与疾病无关的抗体滴度升高更为频繁。我们认为，支原体可能存在于一些慢性支气管炎患者的支气管中，并且虽然此类支原体感染通常无症状，但在被其他病原体感染期间它们可能变得足够活跃，从而刺激支原体抗体反应。
