对雄性大鼠重复给予5-甲氧基-N,N-二甲基色胺可增强血清素激动剂对催乳素分泌的刺激作用。
Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists.
作者信息
Simonovic M, Meltzer H Y
出版信息
Eur J Pharmacol. 1979 Oct 15;58(4):399-405. doi: 10.1016/0014-2999(79)90310-8.
Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.
重复给予5-甲氧基-N,N-二甲基色胺（5MeODMT，5毫克/千克，一种血清素激动剂，每3小时注射一次，共注射4次）可增强其催乳素（PRL）释放作用以及另外两种血清素激动剂——喹哌嗪和N,N-二甲基色胺的催乳素释放作用。这种预处理方案对PRL对抗多巴胺能药物的反应没有影响。PRL对血清素激动剂反应增强的起效是渐进性的，似乎是由于参与PRL分泌调节的血清素机制的致敏作用。文中讨论了这一现象潜在的可能机制。
Zotero 插件