Börner P, Majewski A, Heidenreich W, Werle K P
Geburtshilfe Frauenheilkd. 1979 Sep;39(9):765-74.
A review is presented on 520 patients who had biopsies of the breast which did not show cancer between 1972-1974. These patients are compared to 304 patients whose biopsies definitely showed cancer of the breast and 520 patients who came to the hospital because of well defined gynaecological disease such as uterine fibroids or uterine prolapse. Comparison of these groups regarding age, past history, indications for the biopsy showed that patients with a biopsy without proof of cancer are difficult to follow for diagnosis. Follow-up on these patients is difficult, however, it is important since up to 4% of these patients with previous negative biopsies later have cancer of the breast. A decrease of biopsies in favor of non-surgical diagnosis of breast lesions can only be recommended under optimal conditions. Under other circumstances the risk of cancer of the breast is high enough to justify a liberal indication for breast biopsies.
本文回顾了1972年至1974年间接受乳腺活检但未发现癌症的520例患者。将这些患者与304例活检确诊为乳腺癌的患者以及520例因明确的妇科疾病（如子宫肌瘤或子宫脱垂）前来医院的患者进行比较。对这些组在年龄、既往史、活检指征方面的比较表明，活检未证实癌症的患者难以进行诊断随访。对这些患者进行随访很困难，然而，这很重要，因为这些既往活检为阴性的患者中高达4%后来会患乳腺癌。只有在最佳条件下，才建议减少活检，转而采用乳腺病变的非手术诊断方法。在其他情况下，乳腺癌的风险足够高，足以证明放宽乳腺活检指征是合理的。
